New publication from the OS Lab

Check out our lab’s newest publication, out this month in Journal of Bacteriology! This work was led by former OS graduate student Dr. Louise Djapgne. Dr. Djapgne detailed the biochemical and genetic basis by which the PrrF sRNAs modulate the production of the PQS quorum signaling molecule. This study was performed as a part of our ongoing collaboration with Dr. Sarah Woodson at Johns Hopkins University, and included work from OS Lab members Luke Brewer and Jonathan Gans. Congratulations all on a great publication!

OS Lab research featured by Journal of Bacteriology

Angie Nguyen’s most recent study, demonstrating how iron impacts P. aeruginosa’s  interactions with Staphylococcus aureus, was just accepted for publication by Journal of Bacteriology. P. aeruginosa and S. aureus both commonly infect the lungs of cystic fibrosis (CF) patients. Less appreciated is the knowledge that S. aureus is much more commonly identified in young CF patients, while P. aeruginosa eventually takes its place. P. aeruginosa produces numerous antimicrobial factors that likely contribute to this shift in microbial populations. How these systems drive changes in the microbial make-up of the CF lung remain poorly understood. Angie’s work demonstrates that iron depletion enhances antimicrobial activity of P. aeruginosa towards S. aureus, indicating iron availability may play a critical role in modulating the microbial make-up of the CF lung. Angie’s study, as well as a separate report on P. aeruginosa interactions with S. aureus, are being featured by the Journal of Bacteriology with an accompanying commentary. Congratulations to Angie and our collaborators on being recognized for their awesome work!!

Congratulations to Alexandria on her first lead author paper!!

Alexandria’s work on PrrF and PrrH regulation in Pseudomonas aeruginosa was just accepted for publication by Infection and Immunity! This study establishes the role of the prrF-encoded sRNAs in iron homeostasis and virulence, in particular demonstrating that the prrF locus is required for acute murine lung infection. Congratulations to Alexandria, as well as all of our collaborators who contributed to this study!!

OS lab members have their first publication!

The first paper with OS lab members has been accepted and is in press at Pathogens and Disease! Louise Djapgne and Angie Nguyen helped complete a study on the effects of iron on antibiotic resistance in Pseudomonas aeruginosa. This work was begun by Mandy Oglesby-Sherrouse during her postdoc, and is now forming the basis for Louise’s dissertation studies. Go see the paper!

Louise Djapgne
Angie Nguyen