Associate Professor of Pharmaceutical Sciences, School of Pharmacy
Associate Professor of Microbiology and Immunology, School of Medicine
Mandy has investigated the role of iron in bacterial pathogenesis for over 20 years. In 2005, she completed her doctoral training at The University of Texas at Austin in the Department of Molecular Genetics and Microbiology, where she studied iron and sRNA regulation in Shigella species, the causative agents of bacillary dysentery. Following her graduate training, her postdoctoral studies at the University of Colorado School of Medicine focused on iron and small RNA regulation in Pseudomonas aeruginosa. Mandy joined the faculty at the University of Maryland in 2012, and in 2018 she was promoted to Associate Professor with tenure. Her laboratory employs a variety of approaches to understand the mechanism and impact of iron regulatory pathways of P. aeruginosa. A primary focus of her research program is the development of more biologically relevant in vitro growth systems, which have revealed novel impacts in bacterial iron regulation on virulence trait expression.
Current Funding:
NIH-NIGMS R01GM126376 (MPI with EM Nolan)
“Metallobiochemistry of innate immunity and bacterial physiology”
NIH-NIAID R01AI161294 (MPI with A Wilks)
“Integration of heme acquisition and signaling in Gram-negative pathogens”
Completed Funding:
Cystic Fibrosis Foundation Postdoctoral Fellowship (PI)
“Role of heme in the regulation of Pseudomonas aeruginosa gene expression”
NIH-NIAID K22AI089776 (PI)
“Mechanism of heme regulation of a P. aeruginosa non-coding RNA”
NIH-NIAID R01AI123320 (PI)
“Role of PrrF and PrrH regulation in Pseudomonas aeruginosa physiology”
Cystic Fibrosis Foundation Research Grant
“Iron regulation of CF lung pathogen interactions”
The Oglesby Lab 