Iron and bacterial pathogenesis at the University of Maryland School of Pharmacy

Recent Publications

Chourashi R and Oglesby AG. (2024) Iron starvation induces production of the Pseudomonas aeruginosa RsmY and RsmZ sRNAs in static conditions. J Bacteriol e00278-23.

Peet J, Phan A, Oglesby AG, Nolan EM. (2024) Iron sequestration by murine calprotectin induces starvation responses in Pseudomonas aeruginosa. ACS Infectious Diseases. 10(2) 688-700.

Hoang TM, Huang W, Gans J, Weiner J, Nowak E, Barbier M, Wilks A, Kane MA, Oglesby AG. (2023) The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression. mSphere e00392-23.

Nelson CE*, Huang W*, Zygiel EM, Nolan EM, Kane MA, Oglesby AG. (2021) The human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa. Microbiol Spectr 9(2):e0051921.

Djapge L and Oglesby AG. (2021) Molecular RNA chaperone proteins and their control of bacterial pathogenicity. Review. Front Cell Infect Microbiol 11:604511.

Zygiel EM, Obiesesan AO, Nelson CE, Oglesby AG, Nolan EM. (2020) Heme protects Pseudomonas aeruginosa and Staphylococcus aureus from calprotectin-induced iron starvation. J Biol Chem

Brewer LK, Huang W, Kane MA, Oglesby AG (2020) Static growth promotes PrrF- and 2-alkyl-4(1H)-quinolone regulation of type VI secretion protein expression in Pseudomonas aeruginosa. J Bacteriol 202:e00416-20.

Brewer LK, Jones JW, Blackwood CB, Barbier M, Oglesby-Sherrouse AG, Kane MA (2020) Development and bioanalytical method validation of an LC-MS/MS assay for simultaneous quanititation of 2-akyl-4(1H)-quinolones for application in bacterial cell culture. Analytical and Bioanalytical Chemistry. 412(7):1521-1534.

Nelson CE*, Huang W*Brewer LKNguyen ATKane MAWilks AOglesby-Sherrouse AG. (2019) Proteomic analysis of the Pseudomonas aeruginosa iron starvation response reveals PrrF sRNA-dependent regulation of twitching motility, amino acid metabolism, and zinc homeostasis proteins. Journal of Bacteriology. 201(12):e00754-18.

Zygiel EM, Nelson CE, Brewer LK, Oglesby-Sherrouse AG, Nolan EM. (2019) The human innate immune protein calprotectin induces iron starvation responses in Pseudomonas aeruginosa. Journal of Biological Chemistry. 294 (10):3549-3562.

Djapgne L, Panja S, Brewer LK, Gans J, Kane MA, Woodson SA, Oglesby-Sherrouse AG. (2018) The Pseudomonas aeruginosa PrrF1 and PrrF2 small regulatory RNAs (sRNAs) promote 2-alkyl-4-quinolone production through redundant regulation of the antR mRNA. Journal of Bacteriology. 200(10):e00704-17.

Gans J, Osborne J, Cheng J, Djapgne L, Oglesby-Sherrouse AG. (2018) Sequence-specific affinity chromatography of bacterial small regulatory RNA-binding proteins from bacterial cells. Methods in Molecular Biology 1737:341-350.

Little AS, Okkotsu Y, Reinhart AA, Damron FH, Barbier M, Barrett B, Oglesby-Sherrouse AG, Goldberg JB, Cody WL, Schurr MJ, Vasil ML, Schurr MJ. (2018) Pseudomonas aeruginosa AlgR phosphorylation status differentially regulates pyocyanin and pyoverdine production. mBio 9(1) e02318-17.

Huang W, Brewer LK, Jones JW, Nguyen AT, Marcu A, Wishart DS, Oglesby-Sherrouse AG, Kane MA, Wilks A. (2018) PAMDB: a comprehensive Pseudomonas aeruginosa metabolome database. Nucleic Acids Research 46(D1) D575–D580.

Reinhart AA, Nguyen AT, Brewer LK, Bevere J, Jones JW, Kane MA, Damron FH, Barbier M, and Oglesby-Sherrouse AG. (2017) The Pseudomonas aeruginosa PrrF small RNAs regulate iron homeostasis during acute murine lung infection. Infection and Immunity 85(5).

Damron FH, Oglesby-Sherrouse AG, Wilks A, Barbier M. (2016) Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia. Scientific Reports 6: 39172.

Reinhart AA and Oglesby-Sherrouse AG. (2016) Regulation of Pseudomonas aeruginosa virulence by distinct iron sources. Genes 7(12):126.

Nguyen AT, Jones JW, Camara M, Williams P, Kane MA, Oglesby-Sherrouse AG. (2016). Cystic fibrosis isolates of Pseudomonas aeruginosa retain iron-regulated antimicrobial activity against Staphylococcus aureus through the action of multiple alkylquinolones. Frontiers in Microbiology 7:1171.

Nguyen AT and Oglesby-Sherrouse AG. (2016). Interactions between Pseudomonas aeruginosa and Staphylococcus aureus during co-cultivations and polymicrobial infections. Applied Microbiology and Biotechnology 100(14):6141-6148.

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*Indicates equal contributions.

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