Iron and bacterial pathogenesis at the University of Maryland School of Pharmacy

Tag: Pseudomonas aeruginosa

  • Congratulations to Alexandria on her first lead author paper!!

    Chourashi R and Oglesby AG. (2024) Iron starvation induces production of the Pseudomonas aeruginosa RsmY and RsmZ sRNAs in static conditions. J Bacteriol e00278-23.

    Peet J, Phan A, Oglesby AG, Nolan EM. (2024) Iron sequestration by murine calprotectin induces starvation responses in Pseudomonas aeruginosaACS Infectious Diseases. 10(2) 688-700.

    Hoang TM, Huang W, Gans J, Weiner J, Nowak E, Barbier M, Wilks A, Kane MA, Oglesby AG. (2023) The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression. mSphere e00392-23.

    Nelson CE*, Huang W*, Zygiel EM, Nolan EM, Kane MA, Oglesby AG. (2021) The human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa. Microbiol Spectr 9(2):e0051921.

    Alexandria’s work on PrrF and PrrH regulation in Pseudomonas aeruginosa was just accepted for publication by Infection and Immunity! This study establishes the role of the prrF-encoded sRNAs in iron homeostasis and virulence, in particular demonstrating that the prrF locus is required for acute murine lung infection. Congratulations to Alexandria, as well as all of our…