Iron and bacterial pathogenesis at the University of Maryland School of Pharmacy

OS Lab Conferences 2018

Chourashi R and Oglesby AG. (2024) Iron starvation induces production of the Pseudomonas aeruginosa RsmY and RsmZ sRNAs in static conditions. J Bacteriol e00278-23.

Peet J, Phan A, Oglesby AG, Nolan EM. (2024) Iron sequestration by murine calprotectin induces starvation responses in Pseudomonas aeruginosaACS Infectious Diseases. 10(2) 688-700.

Hoang TM, Huang W, Gans J, Weiner J, Nowak E, Barbier M, Wilks A, Kane MA, Oglesby AG. (2023) The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression. mSphere e00392-23.

Nelson CE*, Huang W*, Zygiel EM, Nolan EM, Kane MA, Oglesby AG. (2021) The human innate immune protein calprotectin elicits a multi-metal starvation response in Pseudomonas aeruginosa. Microbiol Spectr 9(2):e0051921.

The OS Lab has been traveling and sharing our science this summer!

In June, the lab headed to beautiful Estes Park Colorado for the 62nd Annual Wind River Conference on Prokaryotic Biology. This year’s conference was co-chaired by Erin Murphy (Ohio University) and Helen Wing (UNLV), who organized an amazing and diverse group of speakers! Luke Brewer (PhD student) gave an oral presentation entitled “Iron-Regulated Mechanisms of Pseudomonas aeruginosa Alkyl-Quinolone Activity Against Staphylococcus aureus“. Cassie Nelson (postdoctoral fellow), Jonathan Gans (research assistant), and Mandy Oglesby-Sherrouse (PI) presented posters on the lab’s recent -omics efforts to better understand iron, PrrF, and PrrH regulation in P. aeruginosa. Luke also attended the Metabolism of Infectious Diseases Conference held at Colorado State University, where he had another great opportunity to give an oral presentation on his research.

In July, Cassie and Mandy traveled to Ottawa to attend the 11th International Biometals Symposium, where we saw a wonderful mix of chemistry and genetics research into how metals affect a variety biological systems. Mandy gave an oral presentation of our laboratory’s work on the heme-responsive PrrH sRNA of P. aeruginosa, and Cassie presented a poster entitled “Proteomic analysis of iron regulation in Pseudomonas aeruginosa reveals metabolic adaptations and metalloregulatory crosstalk”.

All around it’s been a great summer with a lot of great science. Now it’s time to get back into the lab to discover more great science!